In modern civilization, modern humanity has faced many challenges for religious science. Because it has attempted to negate the transcendental and sacred dimension of religion, as well as its metaphysical aspect, and has made the place and value of man in the universe vulnerable. It has caused a crisis in religious culture and the spread of skepticism in the human sciences, and has expanded the free interpretation of religious texts based on rationality and human faith. This type of approach has led to the emergence of pluralism, scientific and religious privatization, and secularization, and has led to the expression of the truth of the world and man in the system of existence and their compatibility with each other, based on knowledge such as physics, philosophy, modern psychology, and biology, and with a material explanation. Accordingly, today, without paying attention to one's native and authentic religious culture, both the challenges in the field of religious science have increased and, without conditioning or binding it to civilizational infrastructures, Western development patterns and models and technologies are used in the face of modernity. The author's attempt in this article is to use a descriptive-analytical method and an applied approach based on library study, after mentioning the central concepts, to express the question: What are the most important challenges of religious science in modern civilization and the position of man in this field?